There are three common NFL betting lines: the side, total and moneyline.
Side: The side refers to the point spread. While the odds can fluctuate, most sides are -110, meaning you have to bet $110 to win $100.
Cowboys -7 -100
Giants +7 -110
In that example, the Cowboys are a 7-point favorite and must win by more than 7 to win the bet. If the game ends with a 7-point Cowboys win, the bet is a push and you get your money back.
Total: The total also generally has -110 odds on each side. The sportsbook sets a line, such as 48.5, and bettors decide whether the game will go over or under that total.